ASSOCIATIONS OF THE VDR GENE POLYMORPHISMS RS1544410 AND RS10735810 WITH SEVERAL INDICATORS OF BLOOD SERUM IN THE DYNAMICS OF POSTMENO- PAUSAL OSTEOPOROSIS TREATMENT

The role of VDR gene BsmI (rs1544410) and FokI (rs10735810) polymorphisms in postmenopausal osteoporosis formation has been confirmed by the results fairly large number studies. However, pharmacogenetic aspects above have not adequately studied. aim this work is to study serum levels certain biochemical parameters, bone turnover markers, vitamin D parathyroid hormone women with dynamics treatment ibandronic acid, depending on rs1544410 rs10735810 polymorphisms.
 We examined 117 treatment. 12-month course therapy included calcium cholecalciferol according standard regimen. Detection genetic was carried out polymerase chain reaction method real time. Twice, before start at end one, basic as well β-Crosslaps, osteocalcin, 25(OH) were studied blood serum.
 Women are characterized significant decrease β-CrossLaps, osteocalcin alkaline phosphatase (p<0.01), an increase 25(OH)D concentrations (p<0.01). Prior initiation therapy, GG genotype polymorphism associated lower than AA Holders polymorphism, comparison other women, (p<0.01) (before treatment) after treatment), higher treatment).
 obtained can be used develop personalized antiresorptive regimens osteoporosis.